Background: Ischaemic heart disease (IHD) is a global health concern. Research highlights a significant risk association between ethnicity and IHD, with Asian Indians showing a high prevalence and early onset regardless of their country of residence. While understanding risk factors is essential, the perception of being at risk is crucial for behavioural change. Gaps in the literature on IHD and ethnicity hinder effective preventive strategies, which can be addressed through innovative nurse-led interventions like mobile health clinics. Aim: To assess participants' awareness of IHD risk factors and identify factors influencing their current knowledge. Additionally, it seeks to describe and comprehend the perceptions of personal IHD risk factors among first-generation Asian Indian migrants in Australia. Methods: A mixed methods study, with concurrent quantitative and qualitative data collection. Quantitative data was obtained through an online survey utilising a modified Heart Disease Facts Questionnaire. Qualitative data was gathered through semi-structured interviews. Data analysis: Descriptive statistics and multivariable logistic regression were employed to analyse the quantitative data. Qualitative content analysis was used to analyse qualitative data. Integration of data occurred at the reporting and discussion levels. Results: 75.8% of respondent exhibited good knowledge of IHD risk factors. The qualitative interviews of twenty participants, perceived themselves at risk of IHD and did not believe their risk was higher than their peers. Perception of risk was shaped by life experiences, while lifestyle choices were influenced by migration, the role of healthcare professionals, family commitments, and cultural factors. Notably, common themes between quantitative and qualitative findings demonstrated consistent results. Conclusion: This mixed methods study provides valuable insights into IHD risk knowledge and perceptions among Asian Indian migrants. These findings will improve primary and secondary prevention initiatives and support developing the next phase of research: implementing an innovative nurse led health intervention for hard-to-reach high risk populations.