This Rapid Evidence Assessment (REA) investigated the impact of Electronic Medical Record (EMR) implementations on the process and outcomes of nursing handover. Nursing handover involves transferring patient information, responsibility and accountability. Poor or absent clinical handover can negatively impact quality of care, patient safety and outcomes. EMRs are patient information systems that facilitate the real time sharing of patient data. It has been proposed that EMRs may assist in addressing communication issues often associated with poor nursing handover. A database search was conducted in PubMed, CINAHL and Cochrane. Articles for inclusion were studies evaluating the impact of an EMR implementation, where nurses performed shift-to-shift nursing handover in hospital settings. Eleven studies were included, revealing 4 broad themes: use of EMR during handover; nurse satisfaction with the EMR; barriers to use; and enablers to use. While the EMR was routinely used to validate and check information during handover, nurses considered personalised paper-based forms as their preferred handover tools and generally expressed dissatisfaction with using the EMR to facilitate handover. Barriers to EMR use were design-related, with studies emphasising the importance of cognitive support, the lack of nursing engagement and co-design and variations in nurse digital literacy. Enablers to EMR use included nurse engagement and co-design during implementation. No single tool was able to provide nurses with the required situational awareness, nor the necessary cognitive support required during handover. An effective EMR-mediated solution improving efficacy and quality of nursing handover has not yet been realised. Future EMR-mediated solutions must fully appreciate the complexities of nursing handover, the mental workload associated with the task and the definitive qualities of tools to provide this support. This REA has demonstrated the need for nurses to be directly involved in the iterative development and evaluation of these tools to enhance processes and outcomes of nursing handover.